DR. Irene Woo, 艾琳 吴医学博士

美国加州生殖医学中心首席医师

美国妇产科学以及不孕不育与生殖内分泌双认证专家

特长：胚胎移植，第三方辅助生殖，冷冻卵子，卵巢衰退患者的卵子活性，癌症患者生育能力保存，子宫内膜异位症、多囊卵巢综合症、

个人介绍：

毕业于约翰霍普金斯大学的吴医生全名Irene Woo, 是全美知名的辅助生殖专家，从事临床工作8年，尤其擅长胚胎移植。通过早产因子的发现，吴医生找到了移植后，导致胎儿体重变轻和早产的重要原因, 也为此荣获了美国医学界的诸多殊荣。

执业经历：

试管婴儿专家艾琳.吴，女，医学博士，美国权威辅助生殖专家。现任美国加州生殖医学中心首席医师，美国生殖医学学会（ASRM）常务委员、美国妇产科医学学院（ACOG）常务委员，美国不孕不育与生殖内分泌协会（SREI）委员、美国知名辅助生殖期刊主审官，世界试管婴儿权威教材-IVF第四版主编。

试管婴儿专家吴医生出生于宾州费城，她的教育背景如下：

2002-2006年 宾夕法尼亚大学（美国常青藤联盟）完成分子生物学本科

2006-2010年 宾夕法尼亚州立大学医学院完成临床医学博士

2010-2014年 约翰霍普金斯大学医学院完成住院医师实习

2014-2017年 南加州大学医学院辅助生殖与内分泌专家级进修

试管婴儿专家吴医生具备美国妇产科委员会授予的辅助生殖与内分泌认证+妇产科学双重认证。作为全美辅助生殖技术最新最前沿的科研代表，吴医生解决了辅助生殖领域诸多核心问题：包括癌症患者生育能力保持，冻卵高效复苏后移植、卵巢早衰患者的卵子活性保持、早产因子、卵巢早衰因子等。

试管婴儿专家吴医生是全洛杉矶仅有的几位坚持试管婴儿全程跟诊，凡事亲力亲为的医生。秉着医者父母心的行医宗旨，对待所有患者务必保持坦诚、公开、信息透明。作为一个求学多年的女性执业医师，吴医生深切的理解并关心当代都市女性大龄晚婚的真实现状，她十分热衷于现代女性的生育能力保存，为此曾经在诸多女权组织中发表了重要演讲。

在行医的8年中，试管婴儿专家吴医生针对冷冻卵子胚胎移植、卵巢早衰女性的卵子活力保持，多囊卵巢综合症等诸多问题都有独到之处；此外试管婴儿专家吴医生与世界辅助生殖医学届的诸多大牛一同编撰了美国权威辅助生殖教材-美国第四版试管婴儿the 4^th edition of In Vitro Fertilization.

试管婴儿专家吴医生坚信患者千人千面，对待每一个患者都必须要坚持个性化治疗，并在后续跟进中不断优化治疗方案直至最后成功，让每一个女性都能抱到一个健康的baby。

吴医生对于冷冻卵子的重要研究：

冷冻卵子的复苏效率比不上冷冻胚胎，即使到今日，冷冻卵子的复苏效率也没有达到80%。因此单身女性在考虑冻卵的时候，是要提前选择捐精人做成胚胎，还是多做几次冻卵以防失败，始终是个难题。

2017年试管婴儿专家吴医生发表在《ASSISTED REPRODUCTION TECHNOLOGIES》（辅助生殖技术）中的一文成功的解决了卵子冷冻复苏效率不高的问题，经过10年间286例患者的研究，吴医生成功的将冷冻卵子的活产率提高到了冷冻胚胎的同样效率。

吴医生对于早产因子的重要发现：

2017年5月，试管婴儿专家吴医生发表的一篇关于早产因子造成妊娠不良结局的文章《The role of angiogenic markers in adverse perinatal outcomes: fresh versus frozen embryo transfers》，首次革命性的找到了血管生成标志物与胎儿发育的重要关系，在美国辅助生殖界引起巨大轰动。

通过2011-2013年的数据比对，试管婴儿专家吴医生发现，自然受孕的女性中，血管生成因子（VEGF）+ 胎盘生成因子（PIGF）的比例高于试管受孕的女性，连锁冻胚胎移植数据研究，（自然受孕>冻胚胎> 鲜胚胎）明确了影响胎儿早期着床、发育以及早产的重要原因。

吴医生对于早衰因子的重要发现： 

经过10年的临床研究，试管婴儿专家吴医生成功找到了卵巢早衰人群和正常人群的分子表达差异，并成功的定位到了10个特异性microRNA（命名为卵巢早衰因子），吴医生发现有五类生物分子的表达量提高了5-9倍，另外五类的生物分子下降了12-55倍不等。这些生物分子的表达失控，可能是造成卵巢早衰的罪魁祸首。

试管婴儿专家吴医生的重要发现，为未来卵巢早衰的预防以及治疗提供了一个清晰的方向，以小分子表达检测预估卵巢年龄，会将卵巢早衰的风险预估提早10年。

教育背景：

医学本科（Bachelor Degree）| 宾夕法尼亚大学

医学博士(MD Degree) |约翰霍普金斯大学医学院妇产科

住院医师(Residency) | 约翰霍普金斯大学医学院妇产科

专家级进修(Fellowship) |南加州大学医学院生殖内分泌与不孕不育科室

医学资质：

辅助生殖与内分泌 |美国妇产科委员会认证（ABOG）

妇产科 |美国妇产科委员会认证（ABOG）

临床可开展技术：

流体声学造影、促排卵、体外受精、胚胎辅助孵化、胚胎碎片重组、胚胎移植前诊断、输卵管结扎后复原、达芬奇手术机器人系统、宫腔镜、腹腔镜、刮宫术、妇科癌症筛查等 

科研表彰：

ü   Nagey临床研究最佳贡献奖（2014）

ü   太平洋海岸生殖学会青年学者奖（2015）

ü   Vivere科学顾问委员会青年学者奖（2016）

ü   太平洋海岸生殖学会杰出贡献奖（2017） 

患者评价：

2017最佳临床医生 | Distinguished Doctor Award for Clinical Excellence, 2017

2017年度最佳妇科手术医生| Gynecologic Surgery Excellence Award, 2017 

部分发表文章：

1. Garino C, Bihel F, Pietrancosta N, Laras Y, Quéléver G, Woo I, Klein P, Bain J, Bouchner JL, Kraus JL.  New 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones.  Synthesis and biological properties.  Bioorg Med Chem Lett 2005;15:135-8.

2. Swelstad BB, Brezina PR, Johnson CT, Resetkova N, Woo I, Klop L.  Primary infertility associated with neuroendocrine tumor (Carcinoid) of the appendix.  Asian Pac J Reprod 2012;1:152-4.

3. Woo I, Ehsanipoor RM.  Cabergoline therapy for Cushing disease throughout pregnancy.  Obstet Gynecol 2013;122:485-7.

4. Woo I, Birsner ML, Chen CC.  Periurethral cystic mass misdiagnosed:  A case report.  J Reprod Med 2014;59:414-6.

5. Woo I, Seifert S, Hendricks D, Jamshidi RM, Burke AE, Fox MC.  Six-month and 1-year continuation rates following postpartum insertion of implants and intrauterine devices.  Contraception 2015;92:532-5.

6. Woo I, Tobler K, Khafagy A, Christianson MS, Yates MM, Garcia JE.  Predictive value of elevated LH/FSH ratio for ovulation induction in patients with polycystic ovary syndrome.  J Reprod Med. 2015; 60 (11-12):495-500.

7. Ho J, Woo I, Louie K, Salem W, Jabara SI, Bendikson K, Paulson R, Chung K. A comparison of live birth rates and perinatal outcomes between cryopreserved oocytes and cryopreserved embryos. J Assist Reprod Genet. 2017; 34:1359-1366.

8. Woo I, Chan Y, Sriprasert I, Louie K, Ingles S. Stanczyk F, McGinnis LK, Chung K. The role of angiogenic markers in adverse perinatal outcomes: fresh vs frozen embryo transfers. J Assist Reprod Genet. 2017; 34: 1639-1643.

9.  Woo I, Hindoyan R, Landay M, Ho J, Ingles SA, McGinnis LK, Paulson R, Chung K. Perinatal outcomes after natural conceptions vs IVF in gestational carriers: A model to evaluate IVF treatment vs maternal effects.  Fertil Steril.2017; 108: 993-998.

Chapters in Books:

 1. Woo I, Yates MM.  Menstrual disorders:  Endometriosis, dysmenorrhea and premenstrual dysphoric disorder, chapter 38.  In:  Johnson CT, Hallock JL, Bienstock JL, Fox HE, Wallach EE (editors).  The Johns Hopkins Manual of Gynecology and Obstetrics, Fifth Edition, 2015.  Lippincott Williams and Wilkins, Philadelphia, PA.

 2. Woo I, Tobler KJ.  Evaluation of amenorrhea, chapter 39.  In:  Johnson CT, Hallock JL, Bienstock JL, Fox HE, Wallach EE (editors).  The Johns Hopkins Manual of Gynecology and Obstetrics, Fifth Edition, 2015.  Lippincott Williams and Wilkins, Philadelphia, PA.

 3. Woo I, Christianson MS. Reproductive Endocrinology and Infertility, section 4. In: Szymanski LM and Bienstock JL (editors). Johns Hopkins Handbook of Obstetrics and Gynecology, First Edition 2015. McGraw-Hill Education / Medical.

 4. Woo I, Paulson RJ.  Oocyte donation.  In:  Gardner DK, Simon C (editors).  Oocyte donation.  Handbook of In Vitro Fertilization, 4th Edition, CRC Press, Boca Raton, FL.  Submitted 11/30/15.

 5. Woo I, Paulson RJ. Egg and Embryo Donation. Reproductive Medicine Encyclopedia. Vol 5. In Press 2017.

 6. Woo I. Treatment of Gynecological Congenital Anomalies. Handbook of Gynecology. In Press.

 Abstracts:

 1. Woo I, Flanigan E, Aros S, Cassoria F, Troendle J, Mills JL.  Neurological abnormalities in children exposed to large quantities of alcohol in utero.  Poster presentation at the National Institutes of Health Summer Research Symposium, August 3, 2007, Bethesda, MD.

 2. Kerri B, Woo I, Harkins G.  Complication rates of total laparoscopic hysterectomies at a teaching institution.  Resident Research Symposium, April 2012, Penn State University College of Medicine, Hershey, PA.

 3. Woo I, Christianson M, Swelstad B, Yates M, Garcia J.  Bilateral ovarian ectopic pregnancies following intrauterine insemination after unsuccessful oocyte retrieval.  Poster presentation at the 60th Annual Meeting of the Pacific Coast Reproductive Society, April 18-22, 2012, Rancho Mirage, CA.  Fertil Steril 2012;97(Suppl):S31.

 4. Christianson MS, Yates MM, Woo I, Khafagy A, Garcia JE, Kolp LA.  Women of reproductive age receiving gonadotoxic treatment:  Needs assessment and predictive factors for fertility preservation.  Oral presentation at the 68th Annual Meeting of the American Society for Reproductive Medicine, October 20-24, 2012, San Diego, CA.  Fertil Steril 2012;98(Suppl):S8.

 5. Christianson MS, Yates MM, Woo I, Khafagy A, Garcia JE, Kolp LA.  Obstructed hemivagina and ipsilateral renal anomaly (OHVIRA):  Diagnostic features and management of a frequently misdiagnosed syndrome.  Poster presentation at the 68th Annual Meeting of the American Society for Reproductive Medicine, October 20-24, 2012, San Diego, CA.  Fertil Steril 2012;98(Suppl):S222.

 6. Woo I, Tobler K, Khafagy A, Christianson MS, Yates MM, Garcia JE.  Predictive value of elevated LH/FSH ratio for ovulation induction in patients with polycystic ovary syndrome.  Poster presentation at the 60th Annual Meeting of the Society for Gynecologic Investigations, March 20-23, 2013, Orlando, FL.

 7. Woo I, Hendricks D, Obara R, Roxanne JM, Burke AE, Fox MC.  Six month continuation rate following immediate postpartum insertion of intrauterine devices and implants.  Poster presentation at the Conjoint Meeting of the International Federation of Fertility Societies 21st World Congress on Fertility and Sterility and the 69th Annual Meeting of the American Society for Reproductive Medicine, October 12-17, 2013. Boston, MA.  Fertil Steril 2013;100(Suppl):S312.

 8.  Woo I, Stewart K, Christianson MS, Khafagy A, Zhao Y, Wallach E.   v Poster presentation at the Conjoint Meeting of the International Federation of Fertility Societies 21st World Congress on Fertility and Sterility and the 69th Annual Meeting of the American Society for Reproductive Medicine, October 12-17, 2013. Boston, MA.  Fertil Steril 2013;100(Suppl):S434.

 9.  Woo I, Stanczyk F, Patel S, Su IH, Chung K.  Are there longitudinal changes in serum estradiol due to tamoxifen in premenopausal women with breast cancer?  A prospective cohort study.  Poster presentation at the 63rd Annual Meeting of the Pacific Coast Reproductive Society, March 11-15, 2015, Rancho Mirage, CA.  Fertil Steril 2015;103(Suppl):e41.

 10. Hindoyan RH, Woo I, Ingles S, Paulson R, Chung K.  Perinatal outcomes in pregnancies achieved through gestational surrogacy:  Investigating the influence of treatment versus host effects on assisted reproductive technology outcomes.  Poster presentation at the 71st Annual Meeting of the American Society for Reproductive Medicine, October 17-21, 2015, Baltimore, MD.  Fertil Steril 2015;104(Suppl):e221.

 11. Woo I, Ingles S, Sriprasert I, Paulson R, Stanczyk F, Chung K.  The role of angiogenic markers in adverse perinatal outcomes:  Fresh vs. frozen embryo transfers.  Accepted for oral presentation at the 64th Annual Meeting of the Pacific Coast Reproductive Society, March 9-13, 2016, Rancho Mirage, California.

 12. Woo I, Hindoyan R, Pandian R, Stanczyk F, Bendikson K, Chung K.  Do levels of soluble LH receptors predict effectiveness of exogenous gonadotropins in controlled ovarian hyperstimulaton?  Accepted for poster presentation at the 64th Annual Meeting of the Pacific Coast Reproductive Society, March 9-13, 2016, Rancho Mirage, California.

 13. Ho J, Woo I, Bendikson K, Paulson R, Chung K.  Oocyte cryopreservation is as effective as embryo cryopreservation in achieving live births.  Accepted for poster presentation at the 64th Annual Meeting of the Pacific Coast Reproductive Society, March 9-13, 2016, Rancho Mirage, California.

 14. Woo I, Davenport E, Ingles S, Stanczyk F, Chung K, Bendikson K, Paulson R. Imprecise and Inaccurate HCG trigger concentrations. Oral presentation at the 2016 ASRM Scientific Congress & Expo, Oct 15-19, 2016, Salt Lake City, Utah. 

 15. Woo I, Ho J, Granat A, Jones T, Paulson R, Chung K, Bendikson K. Stair-step ovulation induction is not just for clomiphene citrate.  Poster presentation at the 65th Annual Meeting of the Pacific Coast Reproductive Society, March 22-26, 2017, Indian Wells, CA.  Fertil Steril 2017;107(Suppl):e22-3.

 16. Woo I, Ahmady A, Rhodes-Long K, Villaneuva M, Paulson R, Chung K, Arrach N. Detection of mosaicism using Bayesian model.  Poster presentation at the 65th Annual Meeting of the Pacific Coast Reproductive Society, March 22-26, 2017, Indian Wells, CA.  Fertil Steril 2017(Suppl):107:e22.

17.  Woo I, Christenson LK, Gunewardena S, Paulson R, Chung K, Ahmady A, McGinnis LK.  Distinct microRNA suggest differential gene regulation in granulosa cells in young women with normal ovarian reserve compared to young women with diminished ovarian reserve.  Oral presentation at the 65th Annual Meeting of the Pacific Coast Reproductive Society, Outstanding Prize Paper Third Place. March 22-26, 2017, Indian Wells, CA.  Fertil Steril 2017;107(Suppl):e5.